Bioactive Small Molecules
Medchemexpress LLC 4-acetamidobutanoic acid (N-acetyl GABA) | 3025-96-5 | MFCD00020552 | 98.0% | 145.16 g·mol⁻¹ | C6H11NO3 | 1 ML
4-Acetamidobutanoic acid (N-acetyl GABA) is the N-acetylated metabolite of GABA supplied as a research reagent for biochemical and pharmacological studies. It is available both as solids and as ready-to-use aqueous solutions (for example, 10 mM in water, 1 mL). The compound is characterized by formula C6H11NO3, molecular weight 145.16 g·mol⁻¹, and reported purity of approximately 98.0%.
- Ready-to-use 10 mM aqueous solution, 1 mL for immediate use
- High purity (≈98.0%) suitable for research applications
- Well-characterized molecular formula and molecular weight
- Suitable as a metabolite standard or biochemical reagent
- Supplied with safety data sheet and handling recommendations
Medchemexpress LLC HY-113468AS 1mg Medchemexpress, 3-O-Methyldopa D3 CAS:586954-09-8 Purity:>98%
Medchemexpress, HY-113468AS 1mg 3-O-Methyldopa D3 CAS:586954-09-8 3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Caspase-3/7 Inhibitor I,1mg CAS# 220509-74-0
Caspase-3/7 inbibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 mM). It Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. It has been shown to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 µM). Also it has been reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM). Selectivity for caspases-3 and 7 involves unique hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. [1] [2] In some systems inhibition of caspases-3 and -7 can prevent apoptosis and may therefore have important therapeutic implications. Other sizes are also available. Please inqury us for quote.
Cayman Chemical OM173-αA, Purity: ≥95%, CAS: 58286-56-9, 5 mg
A quinone bacterial metabolite; inhibits the growth of the bacteria M. gallisepticum, M. pneumoniae, and S. aureus in vitro (MICs = 0.39-3.13 μg/ml); inhibits the growth of the plant pathogenic fungus P. oryzae (MIC = 3.12 μg/ml) and several species of Trichophyton (MICs = 12.5-25 μg/ml)
Medchemexpress LLC PqsR/LasR-IN-2 | 2071705-93-4 | 98.5% | 398.89 | C21H23ClN4O2 | 5 MG
PqsR/LasR-IN-2 is a small-molecule research inhibitor targeting the PqsR and LasR quorum-sensing systems in Pseudomonas aeruginosa. It is provided as a purified analytical standard for in vitro studies and screening and has a reported off-target hERG inhibition (IC50 1.408 μM).
- Potent inhibitor of PqsR and LasR in P. aeruginosa.
- Suitable for in vitro screening and assay development.
- Reported hERG inhibition with IC50 1.408 μM.
- High purity (98.54%).
- Molecular formula C21H23ClN4O2; molecular weight 398.89.
Medchemexpress LLC IRAK4-IN-14 | 2667681-71-0 | 99.0% | 489.55 | 50 MG
IRAK4-IN-14 (compound 28) is a potent, selective, and orally active IRAK4 inhibitor with an IC50 of 0.003 μM. It exhibits good PK parameters in rats and mice. IRAK4-IN-14 also demonstrates synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL when combined with Acalabrutinib. It is intended for research use only.
- Potent, selective, and orally active IRAK4 inhibitor
- IC50 of 0.003 μM for IRAK4
- Good PK parameters in rats and mice
- Synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL when combined with Acalabrutinib
- Intended for research use only
Medchemexpress LLC L-Leucine-18O2 | 73579-45-0 | 135.17 | 25 MG
L-Leucine-18O2 is an 18O-labeled L-Leucine, an essential branched-chain amino acid (BCAA) known for activating the mTOR signaling pathway. It is suitable for various research applications requiring isotopic labeling.
- Used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Purity: 98%
- Appearance: Solid, white to off-white
- For research use only
Cayman Chemical ETC-1002, Purity: ≥95%, CAS: 738606-46-7, 5 mg
A prodrug form of ETC-1002-CoA; conjugated to CoA by ACSVL1 to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMPK; suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes; prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in DKO mice
QA Bio Inc Alpha-(1-2,3,6)-Mannosidase - 60 µls
Alpha Mannosidase from Jack Bean cleaves α(1-2,3,6)-linked mannose. • This enzyme is often used in conjunction with Core Alpha-(1-6) Mannosidase (E-AM02) if a noncleavable core α(1-6) mannose is present on the substrate. • Source: Jack Bean • EC 3.2.1.24 • Contents: Alpha-(1-2,3,6) Mannosidase in 150 mM sodium phosphate, 0.1 mM ZnCl2 pH 7.5. (pH 7.5). / 200 µl 5x Reaction Buffer 5.0 (250 mM sodium phosphate, pH 5.0). • Specific Activity >3 U/mg • Activity >10 U/ml • Molecular weight two polypeptides of 64,000 and 44,000 daltons • Specificty All Alpha-(1-2,3,6)-linked mannose
Cayman Chemical 2-chloro-N,N-Dimethylcathinone (hydrochloride), Purity: ≥98%, CAS: 856609-26-2, 5 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical Genz-123346, Purity: ≥98%, CAS: 491833-30-8, 50 mg
A glucosylceramide synthase inhibitor (IC50 = 14 nM); reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of ALT, hemoglobin A1c, and non-fasting glucose in ob/ob mice at 120 mg/kg per day; decreases hepatic fat mass and reduces the size and number of hepatic lipid droplets in diet-induced obese mice at 125 mg/kg per day
Medchemexpress LLC Fibronectin Human 500ug
Fibronectin binds collagen fibrin heparin DNA and actin It is involved in cell adhesion motility opsonization wound healing and maintenance of cell shape Fibronectin Protein Human (HEK293 His) is the recombinant human-derived Fibronectin protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC 3,4-dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione | 342416-30-2 | 98.0% | 316.14 g·mol⁻1 | C13H11Cl2NO4 | 5MG
IRES-C11 is a small-molecule inhibitor that selectively blocks c-MYC internal ribosome entry site (IRES)-mediated translation by preventing heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) binding. It reduces c-MYC and cyclin D1 IRES activity in vitro (significant effects observed at ~50 nM) and has shown synergistic anti-glioblastoma effects when combined with mTOR inhibitors. The compound is supplied as a solid powder and as a 10 mM solution in DMSO for research use.
- Selective inhibitor of c-MYC IRES-mediated translation.
- Blocks hnRNP A1 interaction with the c-MYC IRES.
- Reduces c-MYC and cyclin D1 protein levels at nanomolar concentrations.
- Demonstrates synergy with mTOR inhibitors in glioblastoma models.
- Available as powder and as a 10 mM solution in DMSO for in vitro studies.
- High purity (98.01%) and molecular weight 316.14 g·mol⁻1.
Selleck Chemical LLC L-Mimosine 25mg 500-44-7 Leucenol
L-Mimosine (Leucenol) is a non-protein amino acid, and acts as an iron chelator. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC CB1 inverse agonist 2 | 1019839-52-1 | 99.2% | 5 MG
CB1 inverse agonist 2 is an orally active inverse agonist of the cannabinoid CB1 receptor shown to inhibit CP55940-induced hypothermia and anorexia in mouse models. Supplied at high purity for research applications, it is appropriate for preclinical studies and small-scale pharmacology work.
- Orally active CB1 receptor inverse agonist.
- Demonstrated efficacy against CP55940-induced hypothermia and anorexia in mice.
- High purity suitable for research use.
- Molecular formula C24H20ClFN2OS and molecular weight 438.94 g/mol.
- Available in small quantities for preclinical and exploratory studies.