Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical ANTIBODY WAY-181187 10mg
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A 5-HT6 receptor agonist; increases intracellular cAMP levels in HeLa cells expressing 5-HT6 (EC50 = 6.5 nM); selectively binds to 5-HT6 over 5-HT2B, 5-HT2C, and 5-HT7 (Kis = 2,458, 124, and 679 nM, respectively); selective for 5-HT6 over a panel of 31 receptors and ion channels at 100 nM; increases extracellular GABA levels in the rat frontal cortex at 10 mg/kg; reduces schedule-induced polydipsia, an adjunctive model of compulsive disorder, in rats at 178 mg/kg; has antidepressant-like activity in rats at 17 mg/kg and anxiolytic-like activity in rats at 10 and 17 mg/kg
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Medchemexpress LLC Dehydrocrenatidine | 65236-62-6 | 1 MG
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Dehydrocrenatidine | 65236-62-6 | 1 MG
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Apexbio Technology LLC GSK126, 100mg. Cas: 1346574-57-9 MFCD: MFCD23381067. EZH2 inhibitor
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GSK126 is an inhibitor of EZH2 with Ki Value of 93 pM [1].Over-expression of EZH2 has been reported to be correlated with cancer progression and poor prognosis, high grade and high stage in several tumor types. Other sizes are available. Please inqury us for quote.
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Apexbio Technology LLC IWP-2, 50mg. Cas: 686770-61-6 MFCD: MFCD04457599. Wnt production inhibitor,PORCN inhibitor
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IC50: 27 nM for Wnt pathway activityThe Wnt signaling pathway is important in embryonic development as well as the initiation and progression of a number of types of human cancer. Other sizes are available. Please inqury us for quote.
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Apexbio Technology LLC JNK-IN-7, 50mg. Cas: 1408064-71-0 MFCD: MFCD25976765. Selective JNK inhibitor
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JNK-IN-7 is a selective JNK inhibitor with IC50 values of 1.54 nM, 1.99 nM, 0.75 nM to JNK1, JNK2, JNK3, respectively. It also inhibits phosphorylation of c-Jun, which is a direct substrate of JNK kinase. Other sizes are available. Please inqury us for quote.
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Apexbio Technology LLC LY2228820, 100mg. Cas: 862507-23-1 MFCD: MFCD22572532. P38 MAP kinase inhibitor
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LY2228820 is a potent, selective, ATP-competitive small-molecule inhibitor inhibiting - and -isoforms of p38 MAPK with IC(50) values of 5.3nM and 3.2 nM, respectively1. Other sizes are available. Please inqury us for quote.
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Medchemexpress LLC Notoginsenoside FP2 | 1004988-75-3 | 1 MG
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Notoginsenoside FP2 is a dammarane-Type Bisdesmoside isolated from the Fruit Pedicels of Panax notoginseng, and it has the potential to treat cardiovascular disease.
- Purity is 99.61%.
- Molecular weight is 1211.38.
- Molecular formula is C58H98O26.
- Appearance is a white to off-white solid.
- Classified as Terpenoids, Triterpenes.
- Derived from plants, specifically Araliaceae, Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow.
- Soluble in DMSO at 100 mg/mL (82.55 mM), requiring ultrasonic treatment.
- Store at 4°C, protected from light. In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light.
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Cayman Chemical AdIpostatIn A 5mg
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A GPDH inhibitor (IC50 = 4.1 µM); prevents triglyceride accumulation in 3T3-L1 cells when applied at 5-7.5 µM; cytotoxic against fibroblast carcinoma KB cell lines (IC50 = 10.6 µM)
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Cayman Chemical PerfluorodecnsulfonIc AcId 5mg
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A perfluoroalkyl substance; has been found in lake trout
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Cayman Chemical ANTIBODY HDAC8-IN-1 5mg
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An HDAC8 inhibitor (IC50 = 27.2 nM); selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC50s = ≥3,000 nM for all); cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC50s = 7.9, 7.2, and 7 μM, respectively)
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Cayman Chemical ANTIBODY Darusentn 1mg
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An ETA receptor antagonist (Ki = 13 nM in rat aortic vascular smooth muscle cells); inhibits ET-1-induced contractions in isolated rat aortic rings and mesenteric microvessels (pA2s = 8.1 and 7.97, respectively); decreases systolic blood pressure in DOCA-salt hypertensive rats at 50 mg/kg; decreases MAP and LVDP in normotensive pigs at 1 and 5 mg/kg; reduces myocardial infarct size as a percentage of the area at risk in a porcine model of LAD coronary artery ligation-induced ischemia-reperfusion injury
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eMolecules Medchem Express | DPM-1001 (trihydrochloride) | 5mg | 596366461 | HY-121515A | 677.23 | C35H60Cl3N3O3
Medchem Express | DPM-1001 (trihydrochloride) | 5mg | 596366461 | HY-121515A | | 677.230 | C35H60Cl3N3O3
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Cayman Chemical ANTIBODY CD73-IN-1 500ug
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An inhibitor of CD73 (IC50 = ≤316.23 nM for the human FLAG-tagged enzyme in a cell-free assay)
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Cayman Chemical SalvIa offIcnals Rosmnol 5mg
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A polyphenol with diverse biological activities; an inhibitor of α-glucosidase and α amylase (IC50s = 16.4 and 40.9 UG/ml, respectively); induces apoptosis in COLO 205 cells (IC50 = ~42 µM); inhibits LPS-induced PGE2 production, as well as reduces LPS-induced NF-κB, iNOS, and COX-2 activity, in RAW 264.7 macrophages at 2.5 and 5 µM; has antinociceptive, antidepressant-like, and anxiolytic-like activity in mice at 30-100 mg/kg, respectively
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Cayman Chemical ANTIBODY HS-1371 10mg
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A RIPK3 inhibitor (IC50 = 20.8 nM); inhibits basal RIPK3 autophosphorylation and TNF-α- or TRAIL-induced necroptosis in HT-29 cells at 5 µM; inhibits TNF-α Smac mimetic- and Z-VAD-induced necroptosis in HeLa and NCI-H2009 cancer cells ectopically expressing RIPK3
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